Enhanced Production of Santalols by Engineering the Cytochrome P450 Enzyme to the Peroxisomal Surface in Yeast.
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Enhanced Production of Santalols by Engineering the Cytochrome P450 Enzyme to the Peroxisomal Surface in Yeast.（XM-D-P40730492）｜ 文档库 · 论文。香脉香产业数据大库收录条目，附分类信息与采集日期。
- 原始类型
- 论文
- 作者/机构
- Wang
- 出版者
- Journal of agricultural and food chemistry
- 年份
- 2025
- 标准号/DOI/专利号
- 10.1021/acs.jafc.5c05047
- 原文链接
- https://pubmed.ncbi.nlm.nih.gov/40730492/
Cytochrome P450 enzymes are crucial for producing complex plant natural products (PNPs), but their expression and activity in heterologous systems are often limited. This study explores subcellular engineering to improve PNPs production by synthesizing (Z)-santalols─high-value components of sandalwood oil─in GRAS (Generally Recognized As Safe) Saccharomyces cerevisiae. By directing the mevalonate pathway and sandalwood oil biosynthesis enzymes to peroxisomes using the ePTS1 peptide, we increased total…
XM-D-P40730492 ｜ 文档库 ｜ 数据来源与采集日期可在上方属性表核对。