Comparative Analysis of Test Methods for Predicting Dermal Sensitization Potency in Essential Oils: A Component-Based Prediction Model, GARDskin Dose-Response Assay, and Local Lymph Node Assay.

The dose-response adaptation of the genomic allergen rapid detection for skin sensitizers (GARDskin DR) assay is a non-animal method for predicting sensitization potency. This proof-of-concept comparative analysis evaluates outputs from a component-based prediction model (CP), GARDskin DR, and historical local lymph node assays (LLNA), exploring the applicability of CP and GARDskin DR for evaluating the no-expected-sensitization induction level (NESIL) potencies of essential oils. Eight well-studied essential oils …